Mpox is an illness caused by a virus, and this study looks at how the virus behaves in people with advanced HIV. HIV stands for Human Immunodeficiency Virus, which affects the immune system, making it hard to fight infections. This study is important because it will help doctors understand how mpox affects people with weakened immune systems, like those with advanced HIV, and how to better treat and prevent serious illness.
In this study, researchers will observe how the immune system responds to the mpox virus and how the virus spreads in the body. They will also check if the virus becomes resistant to antiviral drugs over time and how treatments for mpox and HIV affect the virus and the immune system. People who are 18 years or older, with a low CD4 count (a measure of immune health), and have confirmed mpox can join. They should be hospitalized but not just for infection control.
- Participation is for adults 18+ with mpox and advanced HIV.
- Researchers will evaluate virus behavior and immune response.
- Participants must be hospitalized due to symptoms.