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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Study on KarXT's long-term safety for Alzheimer's-related psychosis.

Recruiting
55-90 years
All
Phase 3

This study is for people who finished earlier studies about a medicine called KarXT, aimed at helping with psychosis (a mental disorder where reality might seem different) in Alzheimer's Disease. Alzheimer's is a condition that affects memory and thinking. This is an open-label study, which means both the doctors and participants know what treatment is being given. The study will run for a year (52 weeks) to check if KarXT is safe and works well over a long time.

  • This study lasts for 52 weeks.
  • You must have completed one of the previous studies (CN012-0026, CN012-0027, or CN012-0056) to join.
  • Participants must be between 55 and 90 years old and have a caregiver to help them.

Only people who have completed the earlier studies and are healthy enough can join. The study checks for safety risks, like heart issues, through tests and exams. Participants cannot join if they are part of another study or have serious health problems. It's important for participants to understand what the study is about and agree to join it.

Study details
    Psychosis Associated With Alzheimer's Disease

NCT05980949

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

25 April 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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