This study is testing new drugs, called **trevogrumab** and **garetosmab**, with a weight-loss drug, **semaglutide** (Wegovy®). The study has three parts: Part A, B, and C. In Part A, healthy people will test the new drugs to see if they are safe. Parts B and C will involve people with obesity to check if the drugs work well with Wegovy and are safe.
The study will look at how much of the drug is in the body and if it causes any side effects. It will also see if the body makes antibodies (proteins that can block the drug from working).
- The study has three parts and can last for several months.
- Participants must be adults, ages 18 to 80, and meet certain health criteria.
- Participants cannot have diabetes or certain other health issues.
If you're interested in joining, you will need to meet specific health and lifestyle requirements. Please discuss with your doctor if this study is right for you.
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