LCH-IV Study is a collaborative effort to treat children under 18 with Langerhans Cell Histiocytosis (LCH), a disease where certain white blood cells build up and can damage organs. The study uses a mix of vinblastine and prednisone as first-line therapy, which has proven effective for those with disease affecting multiple systems (MS-LCH). There are seven treatment groups based on how the disease presents and responds to treatment. Different groups receive treatments ranging from first-line therapy to monitoring and follow-up.
- Participation requires multiple check-ins and treatment could last up to a year.
- Eligibility depends on age, diagnosis confirmation, and treatment history.
- Risks include side effects from medications; parental consent is needed for participation.
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