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A Study to Assess the Efficacy and Safety of RO7790121 for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

Testing a new treatment for moderate to severe ulcerative colitis.

Recruiting
16-80 years
All
Phase 3

Study Purpose: This study looks at how well a new medicine, called RO7790121, works for people with moderate to severe ulcerative colitis (UC). UC is a condition that causes swelling and sores in the colon. The study compares RO7790121 with a placebo, which is a treatment that doesn't contain active medicine.

Eligibility: Participants must have UC and weigh at least 40 kilograms (about 88 pounds). They should have tried other UC treatments that didn't work well for them. They can't join if they have other bowel diseases, certain infections, or are pregnant.

Key Points:

  • This study is a Phase III trial, meaning the medicine has already shown promise in earlier tests.
  • Participants will be part of the study for both induction and maintenance therapy, which may involve multiple visits.
  • There are risks involved, including possible side effects, and participants should discuss these with their doctor before joining.
Study details
    Moderately to Severely Active Ulcerative Colitis

NCT06589986

Hoffmann-La Roche

10 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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