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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

Testing if chemo before surgery helps nasal and sinus cancer treatment.

Recruiting
18 years and older
All
Phase 2

This study looks at two ways to treat nasal and paranasal sinus cancer that can be removed by surgery. One way uses chemotherapy (special cancer-fighting drugs) before surgery and radiation therapy, while the other way uses just surgery and radiation therapy. Chemotherapy drugs, like docetaxel, cisplatin, and carboplatin, work to kill or stop cancer cells from growing. Radiation therapy uses strong x-rays to shrink tumors. The study aims to see if using chemotherapy before surgery helps keep more of the normal part of the nose and face.

  • The study involves two groups: one with chemotherapy before surgery and one with just surgery and radiation.
  • Participants will have regular follow-ups every 3 months for the first 2 years, then every 6 months for the next 3 years.
  • Eligible participants must be in good health, with no other serious illnesses, and must not have had previous radiation for head or neck tumors.
Study details
    Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7
    Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7

NCT03493425

ECOG-ACRIN Cancer Research Group

31 March 2025

Step 1 Get in touch with the nearest study center
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