This study is testing a drug called disitamab vedotin for treating a type of cancer called urothelial cancer. This cancer affects the bladder and related areas, and in this study, it has spread in the body and can't be removed by surgery. The study is checking if disitamab vedotin works well by itself or when combined with another drug called pembrolizumab. Pembrolizumab is a medicine that helps the immune system fight cancer. The study also examines the safety of the drugs and any side effects, which are unwanted reactions that might happen when taking the medicine.

• This study involves multiple visits and monitoring by doctors over time.
• Participants might receive disitamab vedotin alone or with pembrolizumab.
• Some side effects may occur, and the study will help understand these better.

To join, participants need specific cancer conditions and may have tried some treatments before. The study site will check if you meet all the requirements.