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Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

Studying atorvastatin to prevent hearing loss during cancer treatment.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study aims to see if the drug *atorvastatin*, usually used for lowering cholesterol, can help prevent hearing loss caused by *cisplatin*, a chemotherapy drug used for treating head and neck cancer. People aged 18 and older with a type of cancer called squamous cell carcinoma of the head and neck can participate. Participants will be split into two groups: one taking atorvastatin and the other a placebo (a fake pill that doesn’t contain the active medicine). The study will have three main visits to check hearing before, during, and after cancer treatment. They will also have blood tests twice.

Key Points:

  • The study will last until two years after cancer treatment.
  • Participants must attend three hearing tests and two blood test visits.
  • Participants will be randomly assigned to take atorvastatin or a placebo daily.

By joining, you might help discover if atorvastatin can protect hearing during chemotherapy. However, there may be risks, such as unknown side effects from atorvastatin or increased health risks due to participation.

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Study details
    Hearing Loss
    Head and Neck Cancer

NCT04915183

National Institute on Deafness and Other Communication Disorders (NIDCD)

6 June 2026

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