This study is testing two types of radiation therapy to treat liver cancer: proton and photon therapy. Radiation therapy uses high-energy rays to destroy cancer cells. Photon therapy uses x-rays, while proton therapy uses proton particles that can target the tumor more precisely, potentially causing less harm to nearby healthy tissues.

• The study involves treatments over 15-24 days, followed by regular check-ups for up to 5 years.
• Participants will have multiple scans and blood tests during the study.
• Eligibility requires specific health criteria and consent, and participants must be 18 or older.

The goal is to see if proton therapy helps patients live longer and experience fewer side effects compared to photon therapy. Researchers will also check for differences in how the cancer progresses and how patients feel during treatment. Participants should be aware that the treatment might have risks, and they need to ensure their insurance covers the treatment.