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Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

Testing drug combinations for advanced lung cancer with gene changes.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This trial is for patients with advanced non-small cell lung cancer (NSCLC) who have specific gene changes called EGFR and MET. The study tests different combinations of targeted drugs: capmatinib, osimertinib, and/or ramucirumab. These drugs work by blocking proteins that make cancer cells grow and spread. The goal is to see if these combinations can help shrink or control the cancer.

  • The study involves a comparison between two groups: one receiving all three drugs and another receiving capmatinib and osimertinib only.
  • Participants must have measurable disease, meet specific medical criteria, and be willing to undergo regular scans and blood tests.
  • Compensation and travel details are not specified, but participants must agree to participate in blood sample collection for research.

Eligibility requires previously treated lung cancer with certain gene changes. The study has strict medical and safety criteria, including tests for blood counts and organ function. Participants can't have had recent surgeries, specific drugs, or uncontrolled health conditions. Pregnant or breastfeeding individuals are not eligible, and those who can reproduce must agree to use contraception.

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Study details
    Recurrent Lung Non-Small Cell Carcinoma
    Stage IV Lung Cancer AJCC v8

NCT05642572

SWOG Cancer Research Network

21 June 2025

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