Chronic Exertional Compartment Syndrome (CECS) is a painful condition that affects runners. It happens when too much pressure builds up in the leg muscles. Normally, doctors use a painful needle test to diagnose it, and surgery is the standard treatment, but both are invasive and can be uncomfortable. This study wants to explore a new method using a special type of botulinum toxin (like Botox) called abobotulinumtoxinA to treat CECS. They also want to test a new way to diagnose CECS using a non-painful scan called ultrasound shear wave elastography (SWE), which checks how stiff muscles are.

The study happens at Emory's sports medicine clinic and involves different departments like Physical Therapy and Orthopedics. They will check if the new treatment works and if it can replace surgery. This could make future diagnosis and treatment easier and less painful. The study is open to adult runners aged 18 to 65 who meet certain criteria.

• Participants must be available for regular visits at the clinic during the study.
• The study could help avoid surgery and provide an easier diagnosis method.
• Participants may benefit from a potentially effective, non-invasive treatment.