This study tests a drug called ALN-KHK on people who are overweight or have Type 2 Diabetes Mellitus (T2DM). T2DM is a condition where your body has trouble using sugar properly. The study is in two parts. Part A is for people who are overweight with a Body Mass Index (BMI) between 27 and 34.9. Part B is for people who are obese with a BMI between 30 and 39.9 and have T2DM. The study aims to see how safe the drug is and how it works in the body.
To join, participants should not have changed their thyroid medications for at least 4 months. They should not have received any other experimental drug in the last 30 days. Part A participants should not have any history of diabetes, while Part B participants should have T2DM but not Type 1 diabetes.
- The study involves taking single or multiple doses of the drug.
- Participants will be monitored for safety and how their body reacts to the drug.
- Potential risks and benefits will be explained during the study.