This study looks at two ways to use chemotherapy for removable pancreatic cancer. Pancreatic cancer is a disease where harmful cells form in the pancreas, an organ in your belly that helps digest food. Chemotherapy is medicine that can kill cancer cells or stop them from growing. The study compares giving chemotherapy both before and after surgery (called perioperative chemotherapy) to giving it only after surgery (called adjuvant chemotherapy). The medicines used include fluorouracil, irinotecan, leucovorin, and oxaliplatin. These are given through a vein (IV) and work to stop cancer cell growth.

• Study lasts for about 6 years after treatment completion with regular checkups.
• Participants may receive up to 12 cycles of chemotherapy depending on the study group.
• Participants must not have had previous treatments for pancreatic cancer and must meet certain health criteria.

If you have removable pancreatic cancer, this study might offer a way to see which treatment plan works better. As always, talk to your doctor to understand if joining this study is right for you.