This study looks at how a medicine called **etavopivat** affects blood flow in the brain and muscles of kids with **sickle cell disease** (SCD). Sickle cell disease is a condition where the red blood cells are shaped like sickles and can block blood flow. The study uses special tools, known as **FDNIRS/DCS**, to measure how well blood flows and how much oxygen the brain uses. The study will last up to **38 weeks** for each participant.

Key Points:

• The treatment period is 24 weeks long, with additional visits before and after.
• Participants are compensated for their time and travel.
• Only those with specific types of sickle cell disease and stable health conditions can join.

To join the study, kids must have certain conditions like homozygous hemoglobin SS (HbSS) and not have had recent issues like a sickle cell crisis or major infections. If you're interested, make sure to check with your doctor to see if you meet the requirements.