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Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus

Phase 2 study testing ESK-001 for lupus safety and effectiveness.

Recruiting
18-70 years
All
Phase 2

This study is testing a new treatment called **ESK-001** for people with a disease called **Systemic Lupus Erythematosus (SLE)**. SLE is an illness where the body's defense system mistakenly attacks its own healthy tissues. The study lasts for **57 weeks**: 5 weeks for checking if you can join, 48 weeks of treatment, and 4 weeks of follow-up. Participants will either get ESK-001 or a placebo (a fake treatment) for 48 weeks.

  • **Length of Study**: The study lasts for 57 weeks in total.
  • **Eligibility**: Must have SLE for 6 months, meet certain medical criteria, and be on specific treatments.
  • **Risks**: People with certain other diseases or infections cannot join.

If you have SLE and meet the criteria, this could be a chance to try a new treatment. You will need to stay on your current medications and attend regular visits. There are risks, so it's important to discuss with your doctor if this study is right for you.

Study details
    SLE

NCT05966480

Alumis Inc

7 June 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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