This study is testing a new treatment called **ESK-001** for people with a disease called **Systemic Lupus Erythematosus (SLE)**. SLE is an illness where the body's defense system mistakenly attacks its own healthy tissues. The study lasts for **57 weeks**: 5 weeks for checking if you can join, 48 weeks of treatment, and 4 weeks of follow-up. Participants will either get ESK-001 or a placebo (a fake treatment) for 48 weeks.
- **Length of Study**: The study lasts for 57 weeks in total.
- **Eligibility**: Must have SLE for 6 months, meet certain medical criteria, and be on specific treatments.
- **Risks**: People with certain other diseases or infections cannot join.
If you have SLE and meet the criteria, this could be a chance to try a new treatment. You will need to stay on your current medications and attend regular visits. There are risks, so it's important to discuss with your doctor if this study is right for you.