This study is testing a medicine called BE1116 to see if it helps people with serious injuries and heavy bleeding survive better. It's a **big study** taking place in many locations. People will either get the medicine or a placebo (a fake treatment that doesn't do anything) through an **IV**, which is a way to get medicine directly into the blood.

To join, you need to be at least 15 years old and weigh over 110 pounds. You must have a bad injury with lots of bleeding. You can't join if you've had **CPR** (a life-saving procedure with chest compressions) for over 5 minutes, or if you have certain other injuries or have been on blood thinners recently.

• This study is **randomized**, meaning you might get BE1116 or a placebo.
• There are **no costs** for participating, but you might not get paid.
• **Risks** include side effects from the medicine or placebo.

Participating could help doctors learn how to treat big injuries better in the future.