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A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma

Comparing DVRd treatments for new multiple myeloma patients.

Recruiting
18 years and older
All
Phase 3

This study is for people with newly diagnosed multiple myeloma (NDMM), a type of cancer affecting plasma cells in the blood. The study compares two treatment methods. One method uses a combination of drugs, **Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd)**, followed by a special therapy called ciltacabtagene autoleucel (cilta-cel), which uses the patient’s own altered immune cells to fight cancer. The other method uses the same drug combination, followed by an **Autologous Stem Cell Transplant (ASCT)**, where a patient's own stem cells are used to replace diseased cells.

To join, you need to have measurable NDMM, be suitable for high-dose treatment, and meet certain health criteria. You cannot join if you've had certain previous treatments, recent vaccines, or have specific health issues.

  • The study involves about 750 participants, divided into two groups.
  • Participants will be randomly assigned to one of the two treatment methods.
  • The study aims to see which method works better in stopping disease progression and improving health.
Study details
    Multiple Myeloma

NCT05257083

Stichting European Myeloma Network

31 May 2025

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