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S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

Study on Carvedilol's role in protecting heart health during breast cancer treatment.

Recruiting
18 years and older
All
Phase 3
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  • Technical description (Original)

Carvedilol in Preventing Heart Problems in Patients With Metastatic HER-2 Positive Breast Cancer

This study is examining if carvedilol, a medicine usually used for heart issues, can help prevent heart damage in people with HER-2 positive breast cancer that has spread. HER-2 is a protein that can affect how cancer grows. The study aims to see if carvedilol can protect the heart from side effects of a cancer treatment called trastuzumab. The study will last up to 108 weeks, about two years. Participants will be split into groups: some will take carvedilol twice a day, others will not receive any new treatment, and some will be observed without taking carvedilol. Researchers will check the heart’s health through tests and follow-up visits.

  • Length: Up to 108 weeks (about 2 years).
  • Visits: Regular heart check-ups and follow-up visits are required.
  • No compensation: The study does not mention payment for participants.
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Study details
    Cardiotoxicity
    HER2/Neu Positive
    Metastatic Malignant Neoplasm in the Brain
    Recurrent Breast Carcinoma
    Stage IV Breast Cancer AJCC v6 and v7

NCT03418961

SWOG Cancer Research Network

17 May 2025

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