This study is looking at treatments for very sick COVID-19 patients who are in the hospital. It aims to find medicines that can help these patients recover by reducing the need for machines that help them breathe. Patients who join will have data collected on their health status, such as if they need machines to help them breathe, and how long they stay in critical care. They may also get new treatments being tested. This research is part of a "platform trial," which means it can test more than one treatment at a time to see which works best. Participants will need to give their permission to join the study. **Key Points:** - Trial tests new treatments for hospitalized COVID-19 patients needing oxygen or breathing machines. - Participants must be 18 or older and confirmed to have COVID-19. - Requires consent and involves regular monitoring and data collection. **Eligibility:** Must not be pregnant, have severe liver disease, or be in hospice care.