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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

Join a study testing RGX-314 gene therapy for eye health.

Recruiting
50-89 years
All
Phase 3

RGX-314 Gene Therapy Study for Wet AMD: This study is testing a new treatment called ABBV-RGX-314, designed for people with a condition called neovascular age-related macular degeneration (wet AMD). Wet AMD is a serious eye disease that causes vision loss because of new, leaky blood vessels in the eye. Current treatments require frequent eye injections, which can be burdensome. ABBV-RGX-314 aims to offer a one-time gene therapy option to help improve vision without the need for regular injections.

The study involves around 660 participants and compares two doses of RGX-314 with another treatment called aflibercept. The main goal is to see how well RGX-314 can improve vision compared to aflibercept. People aged 50 to 89 who have been previously treated for wet AMD may be eligible to participate.

  • The study lasts about 2 years and involves several visits to the clinic.
  • Participants will receive compensation for their time and travel.
  • There are risks involved, including possible eye problems, and participants must meet certain health criteria.
Study details
    AMD
    nAMD
    Wet Age-related Macular Degeneration
    wAMD
    WetAMD
    CNV

NCT05407636

AbbVie

14 June 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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