Peripheral Arterial Disease (PAD) is a condition where plaque builds up in the arteries, blocking blood flow to areas like the legs. This can cause pain, especially during physical activities. The study is testing if a drug called Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), which helps bone marrow release stem cells, can improve symptoms and blood flow in PAD patients. Participants will receive injections of GM-CSF or a placebo, which is a substance with no active drug, over two periods of three weeks each, spaced three months apart. The study lasts six months, with a follow-up to check improvements and effects.

• Study duration is six months with follow-up visits.
• Participants will receive injections three times a week.
• Eligibility requires specific health criteria and excludes certain medical conditions.

This study may help find better treatments for PAD, but participants should think about the time commitment and any potential risks.