Baricitinib for Reduction of HIV - CNS

This study wants to find out if a medicine called baricitinib can help reduce HIV in the central nervous system (CNS). The CNS includes your brain and spinal cord. HIV is a virus that attacks the body's immune system, and antiretroviral therapy (ART) helps control it, but can't cure it. Baricitinib is a pill that is already approved for treating arthritis but might help with HIV too. Researchers want to see if baricitinib can reduce the HIV hiding in the CNS by comparing it to a placebo (a pill with no medicine in it). They will use tests like bloodwork, brain scans, and memory tests to check if baricitinib makes a difference.

• The study will involve taking baricitinib or a placebo daily.
• Participants must be adults on continuous ART with controlled HIV levels.
• People with certain conditions like kidney disease or heart issues cannot join.

Before joining, you should discuss with your doctor to understand the risks and benefits.