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Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation

Testing a gentler pre-transplant treatment for partial match donors.

Recruiting
18 years and older
All
Phase N/A

This study is exploring a new method to prepare for a special type of bone marrow transplant called **Haplo-Identical Transplantation**. Before the transplant, patients receive **fludarabine**, a medicine that helps prepare the body, and a moderate dose of **Total Body Irradiation (TBI)**, which uses radiation to kill cancer cells. The study uses **Peripheral Blood Stem Cells (PBSC)** as the source for the transplant. The goal is to check if this approach is safe and effective.

People can join the study if they have a matching family donor and a blood cancer that needs a transplant. They should be physically able to handle treatment (KPS score 70% or higher). They cannot join if they have serious heart, lung, liver, or kidney problems, or certain infections like HIV or hepatitis.

- Participation may involve several hospital visits and treatment sessions.
- There might be risks from the transplant and radiation treatment.
- Eligible candidates should have a related donor and meet health criteria.

Study details
    Hematologic Malignancy

NCT05417971

Northside Hospital, Inc.

19 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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