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Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation

Study on fludarabine and TBI before transplant with a related donor.

Recruiting
18 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is exploring a new method to prepare for a special type of bone marrow transplant called **Haplo-Identical Transplantation**. Before the transplant, patients receive **fludarabine**, a medicine that helps prepare the body, and a moderate dose of **Total Body Irradiation (TBI)**, which uses radiation to kill cancer cells. The study uses **Peripheral Blood Stem Cells (PBSC)** as the source for the transplant. The goal is to check if this approach is safe and effective.

People can join the study if they have a matching family donor and a blood cancer that needs a transplant. They should be physically able to handle treatment (KPS score 70% or higher). They cannot join if they have serious heart, lung, liver, or kidney problems, or certain infections like HIV or hepatitis.

- Participation may involve several hospital visits and treatment sessions.
- There might be risks from the transplant and radiation treatment.
- Eligible candidates should have a related donor and meet health criteria.

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Study details
    Hematologic Malignancy

NCT05417971

Northside Hospital, Inc.

19 April 2025

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