This study is exploring a new method to prepare for a special type of bone marrow transplant called **Haplo-Identical Transplantation**. Before the transplant, patients receive **fludarabine**, a medicine that helps prepare the body, and a moderate dose of **Total Body Irradiation (TBI)**, which uses radiation to kill cancer cells. The study uses **Peripheral Blood Stem Cells (PBSC)** as the source for the transplant. The goal is to check if this approach is safe and effective.
People can join the study if they have a matching family donor and a blood cancer that needs a transplant. They should be physically able to handle treatment (KPS score 70% or higher). They cannot join if they have serious heart, lung, liver, or kidney problems, or certain infections like HIV or hepatitis.
- Participation may involve several hospital visits and treatment sessions.
- There might be risks from the transplant and radiation treatment.
- Eligible candidates should have a related donor and meet health criteria.