Knee osteoarthritis (KOA) is a condition causing chronic knee pain and disability, which affects many older adults. This study aims to find effective, non-surgical ways to manage that pain without relying heavily on opioids, which are strong pain-relieving drugs. The study will test different treatments to see which are best for people with KOA pain. Participants will be divided into two groups: Phase 1 will involve conservative treatments like behavioral therapies and non-opioid medications, while Phase 2 will consider procedural interventions for those needing more help. The goal is to see which treatments work best for different people.

• Study Length: Participants may go through two phases, depending on their response to treatments.
• Visits Needed: Regular evaluations will be required to monitor treatment effectiveness.
• Compensation: Information on compensation for participation will be provided by the study team.

To join, you must have a knee pain score between 4 and 9 and meet certain criteria. Some people will not be eligible if they have severe health issues or certain medical conditions. Pregnant women or those planning to become pregnant cannot participate.