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Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

Comparing new therapy versus standard care for high-risk B-cell lymphoma.

Recruiting
18 years and older
All
Phase 3

This study is looking at a new treatment called **axicabtagene ciloleucel** for people with a type of cancer called large B-cell lymphoma (LBCL). LBCL is a cancer of the white blood cells, which are part of the immune system. The study wants to see if this drug works better than the usual treatments. If you take part in this study, you'll be watched for up to 15 years to see how you do.

To join, you need to have LBCL confirmed by tests and be at high risk as shown by a score system called IPI. You should have only had one cycle of a treatment that includes a drug called rituximab. Your body needs to be in good health overall. Some types of LBCL and other health problems might not allow you to participate.

  • Length: The study includes a follow-up phase for up to 15 years.
  • Visits: You will need to do regular follow-up visits.
  • Risks: There may be risks from the treatment and long-term follow-up.
Study details
    High-risk Large B-cell Lymphoma (LBCL)

NCT05605899

Kite, A Gilead Company

25 May 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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