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A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Testing H5N1 vaccine safety and response in young and older adults.

Recruiting
18-85 years
All
Phase 1/2

This study is checking how safe and effective a new vaccine is against a type of flu called H5N1. The vaccine uses a special method called *messenger RNA (mRNA)* to teach our bodies to fight the flu. The study has two parts: **Phase 1** and **Phase 2**. In Phase 1, they will try different amounts of the vaccine on healthy adults aged 18 to 85, and compare it with a placebo (a fake treatment) to see which dose works best. Phase 2 will use the best dose from Phase 1 and compare it with a regular flu vaccine. People in the study will get two shots of the vaccine, 21 days apart, and they will be checked for reactions and side effects up to 29 days after the first dose.

To join the study, you must be a healthy adult between 18 and 85 years old, and you need to be willing to follow the study rules. You can't join if you have certain health problems, are pregnant, or have been in another flu study before.

  • The study involves multiple visits and injections.
  • Participants will be closely monitored for health and safety.
  • Compensation may be provided for participation.
Study details
    Influenza
    Human

NCT06382311

GlaxoSmithKline

25 May 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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