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Radiosurgery Before Surgery for the Treatment of Brain Metastases

Studying radiosurgery before surgery for brain metastases.

Recruiting
18 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

Radiosurgery Before Surgery for Brain Metastases

This study tests the safety of using stereotactic radiosurgery (SRS) before surgery for patients with brain metastases. Brain metastases are cancers that have spread to the brain. SRS is a type of radiation therapy that targets tumors with high precision. The goal is to see if SRS can help the immune system fight cancer and reduce the chance of cancer coming back after surgery.

Participants are divided into two groups:

  • Group A: Receives SRS for 1-3 sessions over 1-5 days and takes low dose dexamethasone, either by mouth (PO) or through an IV, for 2-21 days until surgery.
  • Group B: Receives SRS for 1-3 sessions over 1-5 days and takes high dose dexamethasone PO or IV for 2-21 days until surgery.

After surgery, participants are monitored for 120 days, then every 12 weeks.

  • Study involves up to 3 SRS sessions and surgery.
  • Participants are followed up for at least 4 months.
  • Participants must be over 18, with evidence of brain metastases.
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Study details
    Metastatic Malignant Neoplasm in the Brain
    Metastatic Malignant Solid Neoplasm

NCT04895592

Emory University

13 December 2024

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