Revumenib Study for Acute Leukemia: This research is for people with certain types of leukemia, a disease where blood cells grow uncontrollably. We're testing a medicine called revumenib in two phases. First, Phase 1 finds the safest dose for patients. Next, Phase 2 checks how well it works and its safety over time.

Phase 1: Participants try different doses of revumenib to find the maximum safe amount. Based on the medicines they take, they join one of six groups. For example, some groups take revumenib alone, while others mix it with other drugs like antifungal medicines or cobicistat.

Phase 2: This phase involves three groups of participants with specific leukemia types. Each group helps us learn more about revumenib's effects on different types of leukemia. Participants need to meet specific health criteria to join, like having certain white blood cell levels and no recent treatments.

• Participants must visit the study site for treatment and check-ups.
• Study length varies by phase and participation in different arms or cohorts.
• There may be risks or side effects from the medication.