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LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

LEGEND Study: Testing EG-70 for bladder cancer treatment options.

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

The LEGEND Study is testing a new non-viral gene therapy called **EG-70** for people with a type of bladder cancer called **NMIBC** (Non-Muscle Invasive Bladder Cancer). **BCG** is a common treatment for bladder cancer, but sometimes it doesn't work (BCG-unresponsive), or some patients haven't been treated with it yet (BCG-naïve). **EG-70** is given directly into the bladder to help the body’s immune system fight the cancer right where it is, without affecting the whole body.

The study has two parts. The first part (Phase 1) will see how safe EG-70 is and figure out the best dose. The second part (Phase 2) will check how well it works. Patients will receive up to four 12-week cycles of treatment and check-ups. If the cancer goes away, they might get more treatment or just regular check-ups.

  • The study includes several visits over approximately one year or more.
  • Participants must be 18 or older and meet certain health criteria.
  • There may be risks, such as side effects from the treatment.
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Study details
    Superficial Bladder Cancer
    Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

NCT04752722

enGene, Inc.

14 June 2025

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