This clinical study is for adults aged 18-65 who have schizophrenia or schizoaffective disorder and have shown violent behavior in the last six months. Participants will receive either clozapine, a medication used to treat schizophrenia, or a usual antipsychotic treatment (TAU), for 24 weeks. The study aims to see if clozapine can reduce violent acts better than the usual treatment. Participants will need to visit the study site for blood tests and physical exams. A special interview, the MacArthur Community Violence Interview (MCVI), will be used to measure violent acts, and the Excitement Factor of the PANSS will be assessed. This is an open-label trial, meaning both doctors and participants will know which treatment they are receiving.
- Study Duration: 24 weeks with regular check-ups.
- Eligibility: Must have schizophrenia or schizoaffective disorder with recent violent history.
- Exclusions: Serious health conditions, pregnancy, or previous negative reactions to clozapine.
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