This study aims to develop a test for early cancer detection. It involves collecting blood and tissue samples from about 10,000 participants across the U.S. We want both people with cancer and those without to join. **Cancer** means a disease where cells in the body grow uncontrollably. Participants must be between 20-79 years old and give consent. Those with cancer should have a confirmed diagnosis and no prior treatment. Non-cancer participants should not have had cancer in the last 5 years and be in good health. **Exclusions** include being pregnant or having a fever recently. Organ or bone marrow transplant recipients cannot join.

• Study Length: Participants will need to provide blood samples and possibly tissue samples.
• Visits Needed: Multiple visits may be required for sample collection.
• Risks: Minimal risks involved, like blood draw discomfort.