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Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Testing a new method for opioid addiction using nerve stimulation.

Recruiting
18-75 years
All
Phase 3

This study explores how a treatment called **Vagal Nerve Stimulation (VNS)** affects people withdrawing from opioids, like certain pain medications or heroin. A vagus nerve is a nerve in your neck that helps control your body's activities. **VNS** uses a small device to send electrical signals to this nerve, similar to a pacemaker. This study uses a non-surgical device by ElectroCore, which is applied to the neck. It's already approved for treating headaches in the US and other conditions in Europe, and has been tested for PTSD with no bad effects. In this study, VNS is being investigated for its safety and ability to reduce cravings and withdrawal symptoms in people with **Opioid Use Disorders (OUDs)**, even though it's not yet approved for OUDs in the US.

  • **Time Commitment:** Stay in a research hospital for about a week.
  • **Procedures:** Includes MRI scans, psychiatric interviews, and physical tests.
  • **Post Study:** Follow-up call 1-3 months after the stay.

To join, you must have OUDs and be willing to undergo supervised withdrawal. You can't join if you're pregnant, have certain medical conditions, or are on specific treatments. Compensation details were not provided.

Study details
    Withdrawal Symptoms
    Opioid Use Disorder
    Opioid Use

NCT05834478

Emory University

30 March 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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