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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Join a trial studying early-onset Alzheimer's caused by genetics.

Recruiting
18-80 years
All
Phase 2/3

Alzheimer's Disease Study is looking for people aged 18-80 who might carry a gene mutation linked to early-onset Alzheimer’s. The study aims to find out if certain drugs can slow down or change the progression of the disease. Participants will undergo tests like brain scans (MRI and PET) and provide blood and spinal fluid samples. The study lasts up to four years, with an option for extra treatment afterward. You don’t have to know if you carry the gene to join, and some participants will receive a placebo (a harmless pill with no effect) instead of the study drug. This helps researchers compare results. The study is double-blinded, meaning neither you nor the researchers will know if you're receiving the study drug or placebo, ensuring fair results.

Here are some key points to consider:

  • The study requires frequent visits for tests and assessments over four years.
  • You may receive compensation for your participation.
  • There is a possibility of receiving a placebo instead of the active drug.
Study details
    Alzheimers Disease
    Dementia
    Alzheimers Disease
    Familial

NCT01760005

Washington University School of Medicine

5 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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