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Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Testing new medications for TNBC patients without complete remission.

Recruiting
18 years and older
All
Phase 3
This study is testing a new combination of drugs, **sacituzumab tirumotecan** and **pembrolizumab**, to see if they work better than current treatments for people with a specific type of breast cancer called **triple-negative breast cancer (TNBC)**. TNBC is a kind of breast cancer that does not have three common markers often found in breast cancer. The study is for people who had treatment but did not have a complete response in surgery. **Pathological complete response (pCR)** means no cancer is found in tissue samples after treatment. The study will check if the new drug combination can help patients live longer without the cancer coming back. **Invasive disease-free survival (iDFS)** means the cancer has not spread to other parts of the body.
  • Participation involves receiving treatment as assigned and regular check-ups.
  • The study is open-label, meaning both doctors and participants know which treatment is being given.
  • Eligibility depends on factors including past treatments and health conditions.
Make sure to discuss any concerns or questions with your doctor before considering joining the study.
Study details
    Triple-Negative Breast Cancer

NCT06393374

Merck Sharp & Dohme LLC

17 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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