This study is about finding new ways to help people with depression who have high **inflammation** (swelling in the body) and **anhedonia** (not being able to feel pleasure). It lasts for 8 weeks, and participants are randomly given either a medicine called **L-DOPA** or a fake pill (placebo), and neither the doctors nor the participants know who gets what—this is called **double-blind**. The study involves around 10 to 12 weeks of time commitment in total. Participants will have lab tests, medical check-ups, and complete tasks to see how their brain and body respond. They will also have **MRI scans**, which are pictures of the brain, to see if the medicine helps. This research is important because many people with depression don't get better with current treatments. The study hopes to find if L-DOPA, a medicine approved by the FDA, can help certain people with depression. Participants must be between 25 to 55 years old and meet certain health criteria to join. They should not have serious illnesses, drug problems, or be pregnant.

• 8-week study with 10-12 weeks total commitment
• Randomized to L-DOPA or placebo
• Involves lab tests, tasks, and MRI scans