This research study is for people with non-cystic fibrosis bronchiectasis (NCFBE), a lung condition where the airways become abnormally wide, causing breathing problems and infections. The study will test a medicine called Trikafta for four weeks to see if it can help people with NCFBE. Trikafta is a mix of three medicines (elexacaftor, ivacaftor, and tezacaftor) that helps the lungs work better in people with cystic fibrosis (CF). NCFBE is similar to CF, but people with NCFBE cannot normally use Trikafta. Researchers will check lung health, quality of life, and weight. Participants may also give a small skin or blood sample for extra testing.

• Study lasts four weeks with regular check-ins.
• Participants must be 30 people with specific lung issues related to NCFBE.
• Participants should not have CF or be pregnant, and must agree to use birth control.