Total knee replacement is a surgery to help people with severe knee pain. After surgery, some patients feel a lot of pain and sickness, which can make it hard to get better quickly. To help with this, doctors are studying a medicine called Methylprednisolone, a glucocorticoid (anti-inflammatory drug) that can reduce pain and swelling. They will compare it to the usual care of just one dose of another medicine called dexamethasone. The study will look at how well the Methylprednisolone taper helps with pain and nausea, and if it reduces the need for pain medicine like opioids. The study will last about 6 months with visits at normal clinic times. Patients will be contacted after surgery at 1-day and 7-10 days later. They are looking for people aged 18 to 95 who are having knee surgery. The study will take place at Emory University.

• Study duration is 6 months with follow-ups shortly after surgery.
• Participants receive either one or two medications to compare effects.
• 200 participants will be enrolled, with no special risk populations mentioned.