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Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Trying a new drug with standard chemo for advanced ovarian cancer.

Recruiting
18 years and older
Female
Phase 1
In this study, doctors are testing a new drug called **ipatasertib** along with the usual chemotherapy treatment for advanced ovarian cancer. Ovarian cancer is when cells in the ovaries grow abnormally. **Ipatasertib** is a medicine that may help stop cancer cells from growing. The chemotherapy drugs, **paclitaxel** and **carboplatin**, are already used to treat ovarian cancer by killing cancer cells or slowing their growth. This study aims to find the safest amount of **ipatasertib** to use with these chemotherapy drugs and to see if this combination works better than chemotherapy alone. **Key Points:** - The study involves taking **ipatasertib** daily and receiving chemotherapy every 21 days for up to 3 cycles. - Participants must be followed up after treatment for 30 and 90 days. - Eligibility includes having advanced ovarian cancer, but no prior ovarian cancer treatments. Certain health conditions may exclude participation. This research will help determine if the new combination treatment is effective and safe for patients with advanced ovarian cancer. Participants in this study will be closely monitored to ensure their health and safety.
Study details
    Fallopian Tube Endometrioid Adenocarcinoma
    Fallopian Tube High Grade Serous Adenocarcinoma
    Ovarian Endometrioid Adenocarcinoma
    Ovarian High Grade Serous Adenocarcinoma
    Primary Peritoneal Endometrioid Adenocarcinoma
    Primary Peritoneal High Grade Serous Adenocarcinoma
    Stage III Fallopian Tube Cancer AJCC v8
    Stage III Ovarian Cancer AJCC v8
    Stage III Primary Peritoneal Cancer AJCC v8
    Stage IV Fallopian Tube Cancer AJCC v8
    Stage IV Ovarian Cancer AJCC v8
    Stage IV Primary Peritoneal Cancer AJCC v8
    Unresectable Fallopian Tube Endometrioid Adenocarcinoma
    Unresectable Fallopian Tube High Grade Serous Adenocarcinoma
    Unresectable Ovarian Endometrioid Adenocarcinoma
    Unresectable Ovarian High Grade Serous Adenocarcinoma
    Unresectable Primary Peritoneal Endometrioid Adenocarcinoma
    Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

NCT05276973

National Cancer Institute (NCI)

22 December 2024

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