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A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK

Exploring new treatments for wet age-related macular degeneration.

Recruiting
50 years and older
All
Phase 3

This study is testing two treatments, **Tarcocimab Tedromer** and **Tabirafusp Tedromer**, to see if they work well and are safe for people with a condition called **neovascular (wet) age-related macular degeneration (wAMD)**. This condition affects the eyes and can make it hard to see. Another treatment, **Aflibercept**, is already used for wAMD, and this study will compare the new treatments to it. **Neovascularization** is when new, unwanted blood vessels grow in the eye, and **macular degeneration** is when the part of the eye that gives you clear vision gets worse over time.

To join the study, you need to have a specific type of eye issue called **choroidal neovascularization (CNV)** and be new to treatment. The study checks if your vision is within a certain range using a test called **BCVA ETDRS**, which measures how many letters you can read on an eye chart. You also need to sign a form saying you understand the study.

  • The study involves regular check-ups to monitor your eye condition.
  • Participants must not have severe vision loss or large areas of damage in the study eye.
  • Being part of the study means trying new treatments, which may have unknown risks.
Study details
    Wet Age-related Macular Degeneration

NCT06556368

Kodiak Sciences Inc

17 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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