LOWER: Lomitapide Observational Worldwide Evaluation Registry is a study that looks at how safe and effective a medicine called lomitapide is over a long time. Lomitapide is a drug used to lower cholesterol. The study will collect information from people around the world who are taking this medicine. It will check if there are any special side effects and how well lomitapide works. The study will also see if doctors are following the rules for giving and checking the medicine.

Who Can Join: People of all ages who are already taking lomitapide can join. They need to understand the study and agree to share their information. For kids, parents or guardians must agree too.

Who Cannot Join: People taking lomitapide as part of a different study or those trying another new medicine can't join unless they stop the other medicine.

• The study is worldwide and long-term, so expect to be part of it for a while.
• No new treatments, just continuing current lomitapide use.
• No specific compensation mentioned for participating.