This study is exploring if the drug metformin can help ease pain by delaying the start of arthritis after an ACL (anterior cruciate ligament) injury. Arthritis, or joint pain, can happen after injuries like an ACL tear. Metformin is usually for diabetes but might help with inflammation, which is swelling and pain. In this study, metformin is compared to a placebo, a fake pill that looks the same but has no medicine, to check if metformin really works. The study will observe if taking metformin after ACL reconstruction can help prevent arthritis.
To join, you must be between 18-45 years old and planning ACL surgery. You can't join if you have conditions like diabetes or if you're pregnant. The study lasts up to 24 months with assessments. The study is double-blind, meaning neither patients nor doctors know who gets the real drug or placebo, to ensure fairness.
- Study Duration: 24 months
- Eligibility: Age 18-45, planned ACL reconstruction
- Key Condition: No previous ACL injuries on the same knee