This study examines a new device called the Aortix, meant to help people with acute decompensated heart failure (ADHF). This condition is when the heart can't pump blood as well as it should, leading to symptoms like swelling and shortness of breath. Some patients don't respond well to diuretics, which are medicines that help remove extra fluid from the body. The study will compare patients using the Aortix device to those just receiving standard medical treatment.

Patients must be 21 or older and have ongoing heart failure symptoms despite treatment. They will be randomly assigned to use the Aortix or continue with their usual care. Some might be part of a special group (a registry) if they need more advanced treatment soon, like a heart transplant.

• The study involves 295 people at 45 sites in the USA and 5 sites outside the USA.
• Participants must meet certain health criteria and not have certain conditions like severe kidney issues.
• The study will help determine if the Aortix is safe and effective compared to regular treatment.