Sepsis is a life-threatening condition where the body's response to an infection causes injury to its own tissues. This study aims to see if using a special protocol before reaching the hospital can help give patients with sepsis antibiotics faster when they get to the Emergency Department (ED). The study involves Emergency Medical Services (EMS) using a **Prehospital Sepsis Protocol** (PRESS), which is a set of guidelines to help EMS identify sepsis early.

The study takes place at three locations, each with EMS and a hospital working together. If a patient shows signs of sepsis, the EMS team will alert the hospital before the patient arrives. This early warning is believed to help hospitals start treatment faster, possibly improving patient outcomes.

• There are two phases: a baseline and an intervention where the protocol is used.
• EMS teams will receive training on how to use the PRESS protocol.
• Eligibility includes specific vital signs and symptoms; exclusions include trauma or pregnancy.

Participation in this study involves following the protocol during EMS transport and at the hospital. There are no direct risks mentioned, but quicker treatment could potentially improve recovery.