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Responding With Evidence and Access for Childhood Headaches

We're studying treatments for children's headaches. Interested in joining our trial?

Recruiting
10-17 years
All
Phase N/A

This study aims to help kids and teens with migraines, a type of headache. Migraines can be very painful and can make it hard for them to do everyday activities. The study will try two ways to help: **Cognitive Behavioral Therapy (CBT)**, which is a kind of talking therapy done through the internet (telehealth), and a pill called **amitriptyline**. Amitriptyline is a medicine that doctors already use to help with migraines. The study will compare how well CBT works alone and how well it works with the pill.

The study lasts about 28 weeks. In the first 4 weeks, participants will record their headaches. Then, for 8 weeks, they will have six online therapy sessions. If they are in the group using amitriptyline, they will slowly increase their dose. Finally, for the last 16 weeks, they'll keep taking the same dose if they're in the pill group and have three more therapy sessions.

  • The study lasts about 28 weeks with several online sessions.
  • Participants may take a medicine called amitriptyline.
  • Must be able to speak and understand English to join.
Study details
    Headache
    Headache Disorders
    Headache
    Migraine
    Migraine
    Migraine Disorders
    Migraine With Aura
    Migraine Without Aura
    Chronic Migraine

NCT05889624

Children's Hospital Medical Center, Cincinnati

14 June 2025

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