This study is testing a new drug called **REL-1017** for people with **Major Depressive Disorder (MDD)**. MDD is a condition where a person feels very sad or hopeless for a long time. The study is **outpatient**, meaning you don't need to stay at the hospital. Participants will still take their usual antidepressants along with either REL-1017 or a **placebo** (a pill with no medicine). The study is **double-blind**, so neither you nor the doctors will know if you are taking REL-1017 or the placebo.

**Key Points to Consider**:

• Duration: The study involves taking the study drug or placebo once a day.
• Eligibility: Must have MDD and be on stable antidepressant therapy.
• Exclusions: Cannot join if you have severe alcohol issues or other major psychiatric disorders.

If eligible, this study might offer a chance to find a better treatment for your depression. However, there are certain rules about health and past treatments that you need to meet to join. Always discuss with your doctor to see if this study is right for you.