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Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

Testing LN-145 for advanced lung cancer treatment.

Recruiting
18-70 years
All
Phase 2

This study tests a new treatment for people with stage IV metastatic non-small-cell lung cancer (NSCLC). The treatment uses a type of cell called Tumor-Infiltrating Lymphocytes (TILs) made from the patient's own cells. This process is called *autologous* TIL therapy. Patients first get a special medicine to prepare their body, then they receive their own TILs, and finally a medicine called IL-2. The study is for those who have tried other treatments but their cancer still grew.

  • **Study Duration**: The length of the study isn't specified, but it involves multiple steps and check-ups.
  • **Risks**: Treatment may involve side effects due to immune system changes and medication effects.
  • **Eligibility**: Must be over 70 years old and have specific type of lung cancer without certain gene changes.

Participants need to meet specific health conditions and are not eligible if they have certain gene mutations, untreated brain tumors, or have had certain treatments recently. It's important to discuss with a doctor to understand if this study is a good fit.

Study details
    Metastatic Non Small Cell Lung Cancer

NCT04614103

Iovance Biotherapeutics, Inc.

28 June 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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