This study is about stress hyperglycemia (SH), which means high blood sugar during stress, like surgery, in people without known diabetes. About 30% of people without diabetes who have surgery get high blood sugar, increasing the chance of complications. The study will see if a diabetes medicine, dulaglutide, can prevent this. Researchers will monitor sugar levels before, during, and after surgery using a device called continuous glucose monitor (CGM). The study includes two parts: observing sugar levels in patients (Aim 1) and giving dulaglutide or a placebo (fake treatment) to see if it helps control sugar levels (Aim 2). Participants are men and women aged 45-80 having general or vascular surgery, with a BMI (body mass index) of 30 or more. They must not have diabetes or take sugar-control medicines. The study is conducted at a research center, with follow-ups for up to 14 days after surgery.
- Participants must visit the clinic before surgery for tests.
- The study lasts up to 14 days after surgery.
- Patients will receive a small payment for participating.