This study is testing how well a combination chemotherapy works for patients with a specific type of kidney cancer called Wilms tumors. These tumors can be newly diagnosed (first found) or relapsed (returned after treatment). Chemotherapy uses strong drugs to kill cancer cells or stop them from growing. The study has two groups, or arms. Arm I uses a treatment called UH-3, and Arm II uses ICE/Cyclo/Topo. Each treatment involves several cycles of drugs given through an IV (a tube into a vein) over a few weeks. Patients may also have surgery, scans, and possibly radiation therapy. After treatment, patients have follow-up visits for up to five years to check their health. Here are three important things to know:
- Length of Study: Treatment lasts several months with follow-up for up to 5 years.
- Visits Needed: Regular hospital visits are required for treatments and check-ups.
- Risks: There could be side effects from the drugs used in chemotherapy.
Eligibility: Patients need to be 30 years or younger and meet certain health criteria to join.