This study looks at how well a drug called **tezepelumab** works and how safe it is for children aged 5 to less than 12 years who have severe asthma. Asthma is a condition that makes it hard to breathe because the airways in the lungs get swollen and narrow. The study compares tezepelumab to a placebo, which is a substance with no active medicine. Kids in the study will either get tezepelumab or a placebo through injections under the skin for 52 weeks. After that, there's a 12-week period to see how they are doing. Some kids might continue with active treatment for another 24 weeks.

Eligibility includes having severe asthma and being on certain asthma medications. The study is not for those with other serious diseases or who have had severe asthma attacks recently.

• The study lasts up to 78 weeks, including treatment and follow-up periods.
• Participants will visit the study center multiple times for check-ups and treatments.
• There may be risks like side effects from injections.