This study is testing a new drug called **IDE161** for people with advanced solid tumors to see if it's safe and works well. A solid tumor is a lump of cancer that forms in the body. The study will also see how IDE161 works with another drug called **pembrolizumab** for advanced endometrial cancer, a type of cancer in the uterus lining.

Participants need to be adults with specific types of cancer that have certain genetic changes, like BRCA1/2. **BRCA1/2** are genes that help repair DNA, and when they don't work right, it can lead to cancer. The study will check how the body handles the drug (pharmacokinetics) and its effects (pharmacodynamics).

There are some conditions that will prevent someone from joining, like having a brain tumor or certain infections.

• The study involves multiple visits and tests.
• Participants may receive compensation for their time.
• There might be side effects, so the safety of IDE161 will be closely monitored.